Asymmetric construction of binaphthyl by the chiral diether-mediated conjugate addition of naphthyllithium to naphthalenecarboxylic acid 2,6-di-t-butyl-4-methoxyphenyl ester.

نویسندگان

  • Mitsuru Shindo
  • Yasutomo Yamamoto
  • Ken-Ichi Yamada
  • Kiyoshi Tomioka
چکیده

Two ways for the synthesis of binaphthyl were examined based on a chiral ligand-mediated asymmetric conjugate addition of 1-naphthyllithium to naththalene-2-carboxylic acid 2,6-di-t-butyl-4-methoxyphenyl esters. The one pot method by conjugate addition-elimination gave a relatively higher enantioselectivity than the two step synthesis based on addition and subsequent oxidative aromatization.

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عنوان ژورنال:
  • Chemical & pharmaceutical bulletin

دوره 57 7  شماره 

صفحات  -

تاریخ انتشار 2009